1. User Interface: Confluence and monday.com have distinct user interfaces. Confluence provides a clean and intuitive interface that focuses on document collaboration and content creation. It offers a robust WYSIWYG editor along with various formatting options. On the other hand, monday.com has a modern and visual interface that emphasizes task management and team collaboration. It utilizes boards and customizable widgets to provide a clear visual representation of projects and tasks.

2. Features and Functionality: While both platforms offer collaboration and project management capabilities, they differ in their feature sets. Confluence excels in document management, knowledge sharing, and enterprise-grade content creation features such as version control, page templates, and macros. Monday.com, on the other hand, shines in task tracking, project planning, and resource management with features like customizable workflows, Gantt charts, and time tracking.

3. Integration Options: Confluence and monday.com offer integration capabilities, but they differ in the scope and variety of integrations available. Confluence, being part of the Atlassian suite, seamlessly integrates with other Atlassian products like Jira, Trello, and Bitbucket. It also supports integrations with popular third-party tools like Salesforce, Slack, and Google Drive. Monday.com, on the other hand, offers native integrations with a wide range of tools, including project management tools like Asana and Wrike, communication tools like Slack and Microsoft Teams, and cloud storage services like Dropbox and OneDrive.

4. Customization and Extensibility: Both Confluence and monday.com allow customization to a certain extent, but their approaches differ. Confluence offers extensive customization options with the ability to create custom spaces, templates, and macros. It also supports the development of custom plugins and extensions using Atlassian's app development framework. Monday.com, on the other hand, focuses on providing a visually appealing interface with customizable boards, columns, and widgets. While it lacks the ability to develop custom plugins, monday.com offers a robust API for extending its functionality.

5. Price and Licensing Model: Pricing and licensing models vary between Confluence and monday.com. Confluence follows a traditional pricing model, offering both self-hosted and cloud-based options with tiered pricing based on the number of users. It also requires a separate license for additional Atlassian products integration. Monday.com follows a per-user pricing model, offering both monthly and annual plans based on the number of users. It includes all features and integrations in a single subscription, without any additional licensing needed.

6. Target Audience: Confluence and monday.com cater to different target audiences. Confluence is primarily used by enterprises and organizations that require robust document management and knowledge sharing capabilities. It is often adopted by software development teams, project management offices, and internal communication departments. Monday.com, on the other hand, targets a broader audience, including small to medium-sized businesses, creative teams, marketing departments, and remote teams. It focuses on simplifying task tracking and project collaboration for teams of any size.

In summary, Confluence and monday.com differ in user interface, features and functionality, integration options, customization, price and licensing models, and target audience. These differences make them suitable for different use cases and organizational needs.