1. Project Structure: Create React App follows a more opinionated structure, providing a default setup with predetermined configurations and conventions. Vue CLI, on the other hand, offers a more flexible structure, allowing developers to choose from various configuration options and customize the project layout to fit their needs.

2. Community and Ecosystem: Create React App benefits from the strong and mature React community, which offers a vast ecosystem of libraries, tools, and resources. Vue CLI, although rapidly growing, has a smaller community, but it also has a dedicated and enthusiastic group of developers contributing to the Vue ecosystem.

3. Learning Curve and Ease of Use: Create React App is known for its simplicity and ease of use, making it beginner-friendly. Vue CLI, while still approachable, may have a slightly steeper learning curve due to its more flexible nature and additional concepts like single-file components. However, Vue CLI provides extensive documentation and tooling that can help developers quickly get up to speed.

4. Configuration Options: Create React App abstracts away the configuration complexity and provides a predefined set of configurations out of the box. Vue CLI, on the other hand, offers a wide range of configuration options, allowing developers to fine-tune their projects according to their specific requirements. This makes Vue CLI more suitable for complex projects with specific needs.

5. Size and Performance: Create React App generates a relatively larger bundle size compared to Vue CLI. React's virtual DOM reconciliation algorithm might result in slightly slower performance in certain scenarios. Vue CLI, with its optimized build process and smaller bundle size, can offer faster initial load times and better performance in smaller applications.

6. Rendering Approach: Create React App uses a virtual DOM to efficiently handle updates and render the UI. Vue CLI, on the other hand, utilizes a reactive dependency tracking system and a virtual DOM-like structure called the Vue render function. This difference in rendering approach can lead to variations in performance and reactivity in different scenarios.

In summary, Create React App and Vue CLI differ in their project structure, community and ecosystem, learning curve and ease of use, configuration options, size and performance, and rendering approach. Developers should consider these differences when choosing between the two tools based on their specific project requirements and familiarity with the frameworks.