1. Data Immutability: Immutable.js focuses on providing immutable data structures and collections, ensuring that data remains unchanged once created. This helps in preventing unintended modifications to data, leading to more predictable code behavior.

2. Persistence Management: Redux Persist, on the other hand, primarily deals with persisting the Redux store state across sessions or page reloads. It enables storing the Redux state in various storage engines like AsyncStorage, localStorage, or custom storage solutions.

3. Library Dependency: Immutable.js is a standalone library focused solely on immutability and data manipulation, whereas Redux Persist is an extension or middleware specifically designed to work with Redux to handle state persistence.

4. Usage Scope: Immutable.js can be used in any JavaScript application beyond Redux, offering general immutable data handling capabilities, while Redux Persist is tightly integrated with Redux and caters specifically to state persistence needs within Redux applications.

5. Performance Impact: Immutable.js operations might introduce overhead in terms of performance due to creating new data structures on every change, while Redux Persist operations may slightly impact application performance during storage and retrieval of state from external storage mechanisms.

6. Community Support: Redux Persist benefits from the strong community backing of the Redux ecosystem, providing extensive documentation, active maintenance, and seamless integration with other Redux libraries, whereas Immutable.js has a dedicated but relatively smaller community focus.

In Summary, Immutable.js and Redux Persist differ in their focus on data immutability, persistence management, library dependency, usage scope, performance impact, and community support.