1. 1. Key difference: Purpose and functionality: Django REST framework is a powerful and flexible toolkit for building Web APIs, while Markdown is a lightweight markup language used for creating formatted text. Django REST framework is specifically designed to enable the creation of RESTful APIs, providing features such as serialization, authentication, and built-in HTTP methods for handling CRUD operations on resources. Markdown, on the other hand, is primarily used for creating well-formatted plain text documents, with minimal HTML-like syntax for headings, lists, links, and other basic formatting elements.

2. 2. Key difference: Data format: Django REST framework uses JSON (JavaScript Object Notation) as the default data format for transferring data between the API and the client applications. JSON is a lightweight and human-readable format that can be easily parsed and generated by a wide range of programming languages. Markdown, on the other hand, does not have any specific data format, as it is focused on human-readable text rather than structured data.

3. 3. Key difference: Client interaction: Django REST framework is typically used for building server-side APIs that can be consumed by client applications, such as web browsers or mobile apps. It provides a set of views and serializers that handle HTTP requests and responses, allowing clients to interact with the API by sending requests and receiving data in JSON format. Markdown, on the other hand, is primarily used for creating static documents that are meant to be read by humans, rather than for dynamic interactions between clients and servers.

4. 4. Key difference: Templating and rendering: Django REST framework provides a templating system for rendering responses in various formats, including HTML, JSON, XML, and others. It allows developers to create reusable templates for generating responses with dynamic data. Markdown, on the other hand, does not have a built-in templating system and is mainly focused on creating static documents with fixed content and minimal dynamic elements.

5. 5. Key difference: Authentication and authorization: Django REST framework includes built-in support for authentication and authorization, allowing developers to easily implement secure APIs that require user authentication or specific permissions for accessing certain resources. It provides authentication classes and permission classes that can be easily configured to control access to API endpoints. Markdown, on the other hand, does not have any built-in authentication or authorization mechanisms, as it is mainly used for creating static documents that do not require user-specific access control.

6. 6. Key difference: Complexity and learning curve: Django REST framework is a comprehensive and feature-rich framework that provides a wide range of tools and functionalities for building APIs. It requires a certain level of understanding of Django and web development concepts, making it more suitable for professional developers with programming experience. Markdown, on the other hand, is a simple and lightweight markup language that can be quickly learned and used by anyone with basic text-editing skills, without requiring extensive programming knowledge.

In Summary, Django REST framework is a powerful toolkit for building Web APIs with features like serialization, authentication, and built-in HTTP methods, while Markdown is a lightweight markup language used for creating well-formatted plain text documents. Django REST framework uses JSON as its default data format and is designed for client-server interactions, while Markdown is mainly used for static documents. Django REST framework includes a templating system and supports authentication and authorization, whereas Markdown does not. Finally, Django REST framework is more complex and requires programming experience, while Markdown is simple and can be used by anyone with basic text-editing skills.