Hi. I guess it all depends on what your goal is. If you wanna make fast prototyping Django or ExpressJNodeJS might be really good candidates. You can write your services quickly and easily by using anyone of them. Maybe we can also put Laravel in the same category.

Symfony is also another application framework that comes with many reusable components. It provides great flexibility with the configuration and dependency management solutions. So that you can inject or override anything, anytime without doing something hack-ish. You don't have to depend on any components that come with the framework and, replace them with whatever you prefer unless encounter any integration issues. I can say that Laravel also provides most of the Symfony futures as it uses its components under the hood. However, my personal experience with Laravel was not so good because it made me feel like I use a modernized version of Codeigniter. But anyway. :) So if I have to choose one of them, I would choose Symfony.

From the backend perspective, all of those have some pros and cons. For example, If strict type declaration is important for you and you don't like code magics like monkey patching etc., maybe Python and NodeJS might not be good candidates and maybe you could choose Symfony/php. However, in this case, you'll be missed out on the most powerful future of NodeJS which is non-blocking io. if you plan to do IO-intensive works, I think it would be a big loss.

So, maybe I can recommend you to have a look at typescript + NestJS also. https://nestjs.com/ The futures that NestJS provides might be a good balance between the strengths of Symfony and NodeJS.

As I'm backend dev., I haven't work too many frontend projects but from my personal experience, I loved ReactJS more than Vue although Vue was simpler. Maybe a front-end developer can give us more helpful details about those.

Hope it helps.

Go with Node.js. There's something really satisfying about being able to use a single language across your entire tech stack. Especially once you integrate GraphQL, which is effectively JSON.

Your second best option is Go, but the ecosystem around Node.js is quite a bit stronger. This will play a big factor when you start building functionality like file management, messaging (especially in real-time), and authentication. The libraries and documentation are just stronger for Node.