1. Caching Mechanism: Nuster primarily focuses on in-memory caching, which allows fast retrieval of frequently accessed data compared to Squid and section.io, which also offer disk-based caching. This difference can significantly impact the performance and speed of the caching system based on the requirements of the website or application.
2. SSL/TLS Termination: Nuster has built-in SSL/TLS termination capabilities, allowing it to handle encrypted traffic efficiently without the need for additional configurations or modules. In contrast, Squid and section.io may require additional setup and configurations to enable SSL/TLS termination, depending on the specific use case and requirements.
3. Dynamic Content Acceleration: Nuster offers dynamic content acceleration through its reverse proxy capabilities, enabling it to efficiently serve dynamic content and APIs. Squid, on the other hand, is primarily focused on caching static content and may not be as optimized for dynamic content acceleration. Section.io also provides dynamic content acceleration features but may have different configurations and dependencies.
4. Ease of Configuration: Nuster is known for its simple and user-friendly configuration options, making it easier for administrators to set up and manage caching rules, policies, and configurations. In comparison, Squid and section.io may have more complex configuration settings and require additional expertise or resources to properly configure and optimize for specific use cases.
5. Support for HTTP/2: Nuster provides support for the latest HTTP/2 protocol, enabling faster and more efficient communication between clients and servers. Squid and section.io may have varying levels of support for HTTP/2, depending on the version and configuration used, which can impact the overall performance and compatibility of the caching system with modern web technologies.
6. Community and Support: The level of community support and documentation available for Nuster, Squid, and section.io varies, with Nuster having a smaller but active community, Squid being a widely used open-source project with extensive documentation, and section.io offering enterprise-level support and services. The availability of community resources and professional support can influence the ease of troubleshooting, maintenance, and scalability of the caching solution.

In Summary, Nuster stands out for its in-memory caching, SSL/TLS termination capabilities, and dynamic content acceleration, while Squid and section.io offer a broader range of features and support options.