1. Key Difference 1: Availability and Source - One major difference between MyGet and NuGet is their availability and source. MyGet is a cloud-based package manager, whereas NuGet is a package manager built into the Microsoft-developed IDEs such as Visual Studio. This means that MyGet can be accessed from anywhere with an internet connection, while NuGet is limited to the specific IDEs it is integrated with.

2. Key Difference 2: Repository Types - Another significant difference lies in the repository types supported by MyGet and NuGet. MyGet allows users to create both public and private repositories, giving them more control over who can access the packages. On the other hand, NuGet primarily focuses on public repositories, making it more suitable for sharing and distributing packages with the wider development community.

3. Key Difference 3: Package Feeds - MyGet offers various types of package feeds, including NuGet feeds, Npm feeds, and even Bower feeds. This means that users can manage packages from different package managers within MyGet. In contrast, NuGet only supports NuGet feeds, limiting the package management capabilities exclusively to the Microsoft ecosystem.

4. Key Difference 4: Workflow and Collaboration - The workflow and collaboration features differ between MyGet and NuGet. MyGet provides features such as build services, package promotion, and the ability to add collaborators, enabling a more streamlined and collaborative development process. NuGet, on the other hand, focuses primarily on package distribution and does not offer extensive built-in collaboration features.

5. Key Difference 5: Pricing and Licensing - MyGet offers both free and paid plans, allowing users to choose the option that best fits their needs. The paid plans provide additional features and increased storage capacity. NuGet, being an open-source package manager, is free to use, and there are no licensing fees associated with it.

6. Key Difference 6: Support and Customization - When it comes to support and customization, MyGet provides dedicated customer support for its users, with options to purchase premium support plans for enhanced assistance. Furthermore, MyGet offers customization options such as custom domain names and branding. NuGet, being a more standardized package manager, does not offer dedicated support or customization options beyond the basic functionality provided by Microsoft.

In Summary, MyGet and NuGet differ in their availability and source, repository types supported, package feeds, workflow and collaboration features, pricing and licensing, as well as support and customization options.