1. Integration with Design Systems: Sketch is known for its strong integration with design systems like Abstract and Plant. On the other hand, MockFlow also offers integration with design systems but is more focused on collaboration features and the ability to create interactive wireframes and prototypes.

2. Platform Compatibility: Sketch is exclusive to Mac users, limiting its accessibility to Windows and Linux users. In contrast, MockFlow is a web-based tool that can be accessed on any platform without the need for specific operating systems.

3. Collaboration Features: While Sketch has limited collaboration features, MockFlow offers robust collaboration tools such as real-time editing, commenting, and version control. This makes it a more suitable choice for teams working on the same project remotely.

4. User Interface Approach: Sketch has a more minimalist and user-friendly interface that is focused on the design aspect. MockFlow, on the other hand, has a slightly more complex interface due to its additional features for wireframing and prototyping.

5. Price Structure: Sketch is a one-time purchase software that requires a separate license for each user. On the contrary, MockFlow offers subscription-based pricing that is more affordable for teams and individuals, especially for those who do not require advanced design features.

6. Prototyping Capabilities: Sketch is primarily a design tool with limited prototyping features. In contrast, MockFlow is designed to excel in prototyping, offering a wide range of interactive elements and gestures to create highly detailed prototypes for web and mobile applications.

In Summary, Sketch and MockFlow differ in terms of integration with design systems, platform compatibility, collaboration features, user interface approach, price structure, and prototyping capabilities.