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What is Karma?
Karma is not a testing framework, nor an assertion library. Karma just launches a HTTP server, and generates the test runner HTML file you probably already know from your favourite testing framework. So for testing purposes you can use pretty much anything you like.
What is Protractor?
Protractor is an end-to-end test framework for Angular and AngularJS applications. Protractor runs tests against your application running in a real browser, interacting with it as a user would.