1. 1. MVC Architecture: Django follows the Model-View-Controller (MVC) architectural pattern, which separates the application logic into three interconnected components. The Model represents the data structure, the View handles the user interface, and the Controller manages the flow of data between the Model and View. On the other hand, HTML5 is not a framework or an architectural pattern, but it is a markup language used for structuring and presenting content on the web.

2. 2. Server-Side vs Client-Side: Django is a server-side framework, meaning that the application logic is processed on the server before being sent to the client's browser. It allows the backend to handle complex operations and interact with databases or other external services. In contrast, HTML5 is a client-side language that runs directly in the client's browser. It is responsible for rendering and displaying the content to the user and can perform simple tasks like form validation or basic data manipulation.

3. 3. Templating Language: Django provides its own templating language, which allows developers to dynamically generate HTML pages based on data received from the server. It supports reusable templates, template inheritance, and provides powerful control structures and filters to manipulate the data. HTML5, on the other hand, does not have a built-in templating language. It is mainly used for structuring the content and adding markup tags to define the elements and their relationships within a web page.

4. 4. Database Support: Django comes with an integrated Object-Relational Mapping (ORM) layer that allows developers to interact with databases using high-level Python code without writing SQL queries explicitly. It supports multiple databases and provides features like automatic table creation, query optimization, and caching. In contrast, HTML5 has no built-in support for databases and does not provide any direct mechanisms for interacting with them.

5. 5. URL Routing: Django has a powerful routing system that maps URLs to specific views and functions within the application. It allows developers to define URL patterns and their corresponding handlers, making it easy to create clean and user-friendly URLs. HTML5 does not have a built-in URL routing mechanism. It relies on the server-side framework or the web server configuration for handling the routing of requests to different resources.

6. 6. Form Handling: Django provides a comprehensive form handling framework that simplifies the process of creating and validating HTML forms. It offers built-in form widgets, form validation, form rendering, and form processing. With HTML5, form handling is primarily done using standard HTML form elements and attributes. It supports basic form validation but does not provide advanced features like error messages or form rendering functionalities.

In Summary, Django is a server-side MVC framework with a powerful templating language, integrated database support, URL routing, and advanced form handling capabilities. HTML5 is a client-side markup language used for structuring and presenting content on the web without built-in support for server-side processing, templating, database interaction, URL routing, or advanced form handling.