1. Interaction Styles: Framer offers a wide range of interaction styles, including tap, swipe, scroll, and drag, allowing designers to create complex and interactive prototypes. ProtoPie, on the other hand, focuses more on micro-interactions and offers a unique "trigger-reaction" system, making it easier for designers to create detailed and precise interactions.

2. Code vs. Codeless: Framer has a strong emphasis on code and provides a platform for designers to write custom code to create advanced prototypes. ProtoPie, on the other hand, is a codeless tool that focuses on visual interaction design, allowing designers to create interactions through a user-friendly interface without the need for coding knowledge.

3. Platform Compatibility: Framer is primarily built for designing prototypes for web and mobile applications, offering support for iOS, Android, and web platforms. ProtoPie, on the other hand, goes beyond traditional platforms and allows designers to create prototypes for a wide range of devices, including smartwatches, IoT devices, and voice assistants.

4. Collaboration Features: Framer provides collaboration features that allow designers to work together in real-time, providing feedback, and making changes collaboratively. ProtoPie, on the other hand, focuses more on sharing and testing prototypes, providing features to easily share prototypes with stakeholders and gather feedback.

5. Complex Animations: Framer excels in creating complex animations and transitions, allowing designers to create highly polished and realistic prototypes. ProtoPie, on the other hand, offers a more simplified approach to animations, making it easier for designers to create dynamic and interactive prototypes without the need for complex animations.

6. Learning Curve: Framer has a steeper learning curve, especially for designers who are not familiar with coding. It requires a good understanding of JavaScript to utilize its full potential. ProtoPie, on the other hand, is more beginner-friendly and offers a more intuitive interface, allowing designers to quickly learn and create prototypes without the need for coding knowledge.

In Summary, Framer provides advanced interaction styles with a focus on code and complex animations, while ProtoPie offers a codeless approach with a wide range of platform compatibility and collaboration features.