DigitalOcean was where I began; its USD5/month is extremely competitive and the overall experience as highly user-friendly.

However, their offerings were lacking and integrating with other resources I had on AWS was getting more costly (due to transfer costs on AWS). Eventually I moved the entire project off DO's Droplets and onto AWS's EC2.

One may initially find the cost (w/o free tier) and interface of AWS daunting however with good planning you can achieve highly cost-efficient systems with savings plans, spot instances, etcetera.

Do not dive into AWS head-first! Seriously, don't. Stand back and read pricing documentation thoroughly. You can, not to the fault of AWS, easily go way overbudget. Your first action upon getting your AWS account should be to set up billing alarms for estimated and current bill totals.

We first selected Google Cloud Platform about five years ago, because HIPAA compliance was significantly cheaper and easier on Google compared to AWS. We have stayed with Google Cloud because it provides an excellent command line tool for managing resources, and every resource has a well-designed, well-documented API. SDKs for most of these APIs are available for many popular languages. I have never worked with a cloud platform that's so amenable to automation. Google is also ahead of its competitors in Kubernetes support.

If you want to integrate your cluster and control end to end your pipeline with AWS tools like ECR and Code Pipeline your best option is ECS using a EC2 instance. There are pros and cons but it's easier to integrate using cloud formation templates and visual UI for approvals, etc. ECS is free, you need to pay only for the EC2 instance but unfortunately, it is not standard then you cannot use standard tools to see and manage your Kubernetes. EKS in the other hand uses standard Kubernates definitions but you need to pay for the service and also for the EC2 instance(s) you have in your cluster.

GCE is much more user friendly than EC2, though Amazon has come a very long way since the early days (pre-2010's). This can be seen in how easy it is to edit the storage attached to an instance in GCE: it's under the instance details and is edited inline. In AWS you have to click the instance > click the storage block device (new screen) > click the edit option (new modal) > resize the volume > confirm (new model) then wait a very long time. Google's is nearly instant.

• In both cases, the instance much be shut down.

There also the preference between "user burden-of-security" and automatic security: AWS goes for the former, GCE the latter.

Most bioinformatics shops nowadays are hosting on AWS or Azure, since they have HIPAA tiers and offer enterprise SLA contracts. Meanwhile Heroku hasn't historically supported HIPAA. Rackspace and Google Cloud would be other hosting providers we would consider, but we just don't get requests for them. So, we mostly focus on AWS and Azure support.